𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of isotopically labelled AZD3409 and its metabolites

✍ Scribed by Julie A. Bergin; Ryan A. Bragg; Nick Bushby; John R. Harding; Angela Jordan; David A. Killick; Claire L. Silcock


Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
202 KB
Volume
50
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis of stable isotopically labelle
✍ Calvin O Manning; Alan H Wadsworth; Ian Fellows 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 102 KB

## Abstract Lamotrigine is a sodium channel antagonist used for the treatment of epilepsy. Synthesis of stable isotopically labelled (SIL) [M+7] versions of Lamotrigine **(1)** and its __N__‐methylated metabolite **(2)** are described. The routes to prepare these compounds used [M+5] labelled [^13^

Synthesis of isotopically labelled ZD405
✍ Julie A. Bergin; Helen Booth; Ryan A. Bragg; Nick Bushby; John R. Harding; Angel 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 92 KB
Synthesis of isotopically-labelled ethyl
✍ Daniel R. Doerge; Niranjala M. Cooray; Austin B. K. Yee; Walter P. Niemczura 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 142 KB

## Abstract ^13^C‐, ^14^C‐ and ^15^N‐labelled ethylenethiourea was synthesized for NMR and radiotracer applications in metabolism and environmental fate studies. The products contained stable isotopes at 99% enrichment and the radiolabelled product had specific activity of 2.0 mCi/mmole.

Synthesis of isotopically labelled salic
✍ D. R. Hawkins; R. W. Pryor 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 299 KB

## Abstract [^13^C‐carboxyl]Salicylic acid has been prepared by carbonation of 2‐benzyloxybromobenzene followed by reductive debenzylation. Deuterium and tritium labelled salicylic acid and ^2^H~2~/^13^C‐salicylic acid were prepared by reduction of the 3,5‐dibromo derivatives using Raney Ni‐Al. Deu

Synthesis of labeled ambroxol and its ma
✍ Bachir Latli; Matt Hrapchak; Heinz-Karl Switek; Daniel M. Retz; Dhileepkumar Kri 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 253 KB

## Abstract Ambroxol is a mucolytic agent used in the treatment of respiratory diseases. Herein, we report the synthesis of carbon‐14‐labeled ambroxol with the radioactive atom(s) either on the benzylic carbon or uniformly in the cyclohexyl ring with specific activities of 59 and 81 mCi/mmol, respe

Synthesis of isotopically labelled amino
✍ David O. Rees; Nick Bushby; John R. Harding; Chuanjun Song; Christine L. Willis 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 93 KB

## Abstract An efficient approach to the enantioselective synthesis of a series of amino acids from either bromoacetyl bromide or glycine is described using a [2,3]‐sigmatropic rearrangement to establish the stereogenic centre at C‐2 under mild conditions. Protected allylglycine **5** is a valuable