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Synthesis of isotopically labelled salicylates

✍ Scribed by D. R. Hawkins; R. W. Pryor

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
299 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[^13^C‐carboxyl]Salicylic acid has been prepared by carbonation of 2‐benzyloxybromobenzene followed by reductive debenzylation. Deuterium and tritium labelled salicylic acid and ^2^H~2~/^13^C‐salicylic acid were prepared by reduction of the 3,5‐dibromo derivatives using Raney Ni‐Al. Deuterium labelled salicylic acid containing up to four deuterium atoms was prepared by catalytic exchange with Raney Ni‐Al in 5% NaOD/D~2~O.

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