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Facile synthesis of 4,5-disubstituted-3(2H)-pyridazinones

✍ Scribed by Paul S. Humphries; Robert M. Oliver


Book ID
108285509
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
233 KB
Volume
50
Category
Article
ISSN
0040-4039

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The efficient one-pot bis-functionalization of the 4,5-positions of the 3-pyridazinone ring has been performed using Suzuki, Sonogashira and Stille cross-coupling reactions assisted by a retro-ene fragmentation. This route allows access in a shorter synthetic sequence to several pharmacologically us