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Pyridazines. Part 34: Retro-ene-assisted palladium-catalyzed synthesis of 4,5-disubstituted-3(2H)-pyridazinones

✍ Scribed by Eddy Sotelo; Alberto Coelho; Enrique Raviña

Book ID
104253733
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
99 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

The efficient one-pot bis-functionalization of the 4,5-positions of the 3-pyridazinone ring has been performed using Suzuki, Sonogashira and Stille cross-coupling reactions assisted by a retro-ene fragmentation. This route allows access in a shorter synthetic sequence to several pharmacologically useful 3(2H)-pyridazinones.

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