Facile Synthesis of (2S,1′S,2′S)-2-(Carboxycyclopropyl)glycine, an Isotype-Selective Agonist of Metabotropic Glutamate Receptors
✍ Scribed by Dawei Ma; Zhaochun Ma
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 501 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Straightforward stereocontrolled synthesis of (2S)-2-hydroxymethylglutamic acid was achieved from (S)-pyroglutaminol, through a bicyclic silyloxypyrrole derived from the versatile unsaturated lactam 3.
The synthesis of two isotype-selective antagonists for metabotropic glutamate receptors, (2S, l'S,2'S)-2-methyl-2-(carboxycyclopropyl)glycine and (S)-2-amino-2methyl-4-phosphonobutyric acid from L-alanine is described. (~) 1997 Elsevier Science Ltd. All fights reserved.
## Synthesis of (2S,1'S,2'S)-2-Methyl-2-(carboxycyclopropyl)glycine (XIII) and (S)-2-Amino-2-methyl-4-phosphonobutyric Acid (VII)