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Stereoselective synthesis of (2S)-2-hydroxymethylglutamic acid, a potent agonist of metabotropic glutamate receptor mGluR3

✍ Scribed by Prabir K Choudhury; Bao Khanh Le Nguyen; Nicole Langlois

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 54 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)02196-7

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✦ Synopsis

Straightforward stereocontrolled synthesis of (2S)-2-hydroxymethylglutamic acid was achieved from (S)-pyroglutaminol, through a bicyclic silyloxypyrrole derived from the versatile unsaturated lactam 3.

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