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Facile synthesis of 2,4-diamino-6-alkyl- or 6-aryl-pyrimidine derivatives

✍ Scribed by Xihong Wang; Ramadas Sathunuru; Victor Melendez; Michael P. Kozar; Ai J. Lin

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
126 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image Facile methods were developed to prepare a series of 6‐phenyl and 6‐alkyl‐2,4‐diaminopyrimidine derivatives. The pyrimidine ring of the final products was constructed by treatment of a 1,3‐dicarbonyl derivative with an amidine or guanidine. The 6‐phenyl‐pyrimidine derivatives were also prepared by Suzuki coupling reaction, using 2‐methylthio‐4,6‐dichloropyrimidine as the starting material. J. Heterocyclic Chem., (2010).

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