Facile synthesis of 2-substituted benzoxazoles via ketenes
β Scribed by T.O. Olagbemiro; M.O. Agho; O.J. Abayeh; J.O. Amupitan
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 187 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0165-0513
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## Abstract 2βAminophenols react with an array of carboxylic acids in dioxane at 180Β° in the presence of tin(II) chloride to afford the corresponding 2βsubstituted benzoxazoles in good yields. The reaction is applicable to a wide range of alkyl, alkenyl, aryl carboxylic acids.
Direct coupling of 1,1-dibromoethenes with 2-aminophenols had been achieved to form the corresponding benzoxazoles under mildly basic reaction conditions. A variety of substituted 2-aminophenols provided the desired products in moderate to good yields. Even though 1,1-dibromoethenes have to be deriv
## Abstract magnified image 2β(1__H__βPyrrolβ2βyl)benzo[__d__]oxazoles, 4β(benzo[__d__]oxazolβ2βyl)quinoline and 2β(benzo[__d__]oxazolβ2βyl)β4,6βdimethylquinolines were obtained in good yield by the oxidative intramolecular ring closing reactions of phenolic Schiff's bases with the effect of manga