Facile synthesis of benzoxazoles from 1,1-dibromoethenes

✍ Scribed by Kemei Tao; Jianlong Zheng; Zhaogui Liu; Wang Shen; Jiancun Zhang

• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 709 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.04.071

✦ Synopsis

Direct coupling of 1,1-dibromoethenes with 2-aminophenols had been achieved to form the corresponding benzoxazoles under mildly basic reaction conditions. A variety of substituted 2-aminophenols provided the desired products in moderate to good yields. Even though 1,1-dibromoethenes have to be derived from arylcarboxaldehydes or glyoxalate for the reactions, this method still provides a new route to the preparation of benzoxazoles, complementing to existing synthetic strategies.