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Facile solid phase synthesis of an activated diazo linker

✍ Scribed by Gurdip Bhalay; Andrew R. Dunstan

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 189 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01706-7

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✦ Synopsis

The synthesis of a resin bound diazo species has been achieved in a highly efficient manner starting from commercially available reagents. This has produced an activated linker, providing a chemoselective method for the attachment of functionalised carboxylic acids to the solid phase via the Wang linker, in a rapid and colourometric reaction.

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