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Facile Methods for the Synthesis of 5-Aryl and 5-Iodo Pyrrolo[2,3- d ]pyrimidines

✍ Scribed by Venkata Rao, K.; Raghu Prasad, M.; Raghuram Rao, A.


Book ID
121813805
Publisher
Journal of Heterocyclic Chemistry
Year
2014
Tongue
English
Weight
561 KB
Volume
51
Category
Article
ISSN
0022-152X

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A new and versatile synthesis of 5-subst
✍ DolorΓ¨s Edmont; David M Williams πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 80 KB

We have developed a new methodology for the construction of 5-substituted pyrrolo [2,3-d]pyrimidines that involves the reduction of a nitroalkane to an oxime using the reducing ability of the Sn(SR 3 ) -species, followed by mild, acid-catalysed deoximation of the resulting adduct using Dowex-H + res