A new and versatile synthesis of 5-subst
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Dolorès Edmont; David M Williams
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Article
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2000
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Elsevier Science
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French
β 80 KB
We have developed a new methodology for the construction of 5-substituted pyrrolo [2,3-d]pyrimidines that involves the reduction of a nitroalkane to an oxime using the reducing ability of the Sn(SR 3 ) -species, followed by mild, acid-catalysed deoximation of the resulting adduct using Dowex-H + res