Facile Access to N-Thiazolyl α-Amino Acids from α-Bromo Ketones and α-Amino Acids
✍ Scribed by Joachim Rudolph
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 106 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
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✦ Synopsis
AbstractÐN-Substituted 2-aminothiazoles are synthesized in a one-pot procedure using readily available a-bromo ketones and amines. This method is compatible with a wide range of functional groups and offers a facile and ef®cient access to the class of N-thiazolyl a-amino acid derivatives.
📜 SIMILAR VOLUMES
## Abstract Diazotization of α‐amino acids in 48:52 (__w__/__w__) hydrogen fluoride/pyridine along with excess of potassium halide results in the corresponding α‐halocarboxylic acids in good to excellent yields __(Table 1__ and __2)__.
p. 521, line 9, phthaloyl should be phthalyliminonethyl. p. 521, line 10, propenoate (la) should be butanoate (la). p. 521, line 11, pentenoate (6i) should be buterloate (6a). ## F. 5Z, Table 1, Value of NMR spectrum should be ppm.
In previous papers, l-3 we reported the synthesis of a,S-unsaturated N-acyla-amino acid ester (1) by the condensation of ethyl a-oxocarboxylate with amide or by the treatment of N-acetoxy-N-acyl-a-amino acid ester with Et3N. Up to date,
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