Enantioselective preparation of α-acyloxy ketones from α-hydroxy and α-amino acids
✍ Scribed by Gérard Cahiez; Eric Metais
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 266 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract Diazotization of α‐amino acids in 48:52 (__w__/__w__) hydrogen fluoride/pyridine along with excess of potassium halide results in the corresponding α‐halocarboxylic acids in good to excellent yields __(Table 1__ and __2)__.
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AbstractÐN-Substituted 2-aminothiazoles are synthesized in a one-pot procedure using readily available a-bromo ketones and amines. This method is compatible with a wide range of functional groups and offers a facile and ef®cient access to the class of N-thiazolyl a-amino acid derivatives.