Extended kinase profile and properties of the protein kinase inhibitor nilotinib
✍ Scribed by Paul W. Manley; Peter Drueckes; Gabriele Fendrich; Pascal Furet; Janis Liebetanz; Georg Martiny-Baron; Jürgen Mestan; Jörg Trappe; Markus Wartmann; Doriano Fabbro
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 830 KB
- Volume
- 1804
- Category
- Article
- ISSN
- 1570-9639
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## Abstract For Abstract see ChemInform Abstract in Full Text.
Protein kinases are now the second largest group of drug targets, and most protein kinase inhibitors in clinical development are directed towards the ATP-binding site. However, these inhibitors must compete with high intracellular ATP concentrations and they must discriminate between the ATP-binding
The role of protein kinase C in insulin signal transduction is controversial It has been postulated that protein kinase C is activated by insulin and that the kinase is directly involved in insulin-mediated metabolic processes In opposition to this view is the hypothesis that protein kinase C is not