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Macrocyclic Bisindolylmaleimides as Inhibitors of Protein Kinase C and Glycogen Synthase Kinase-3.

โœ Scribed by Han-Cheng Zhang; et al. et al.


Publisher
John Wiley and Sons
Year
2003
Weight
120 KB
Volume
34
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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Modulation of protein kinase FA/glycogen synthase kinase-3a (kinase FA/GSK-3a) by reversible tyrosine phosphorylation/dephosphorylation was investigated. In addition to genistein, other protein tyrosine kinase (PTK) inhibitors, such as tyrphostin A47 and B42, also could induce tyrosine dephosphoryla