✦ LIBER ✦

Protein kinase C: Mediator or inhibitor of insulin action?

✍ Scribed by R. V. Considine; J. F. Caro

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 675 KB
Volume: 52
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240520103

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✦ Synopsis

The role of protein kinase C in insulin signal transduction is controversial It has been postulated that protein kinase C is activated by insulin and that the kinase is directly involved in insulin-mediated metabolic processes In opposition to this view is the hypothesis that protein kinase C is not activated by insulin and, more importantly, may be responsible for attenuation of the insulin signal The evidence for and against protein kinase C as a mediator of the insulin signal will be put in perspective followed by discussion of the possible role of the kinase in the pathogenesis of insulin resistance in type II diabetes

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