Expression, Purification, and In Vivo Administration of a Promising Anti-Idiotypic HIV-1 Vaccine
โ Scribed by Johannes Simon Gach; Heribert Quendler; Boris Ferko; Hermann Katinger; Renate Kunert
- Book ID
- 107581604
- Publisher
- Humana Press Inc
- Year
- 2008
- Tongue
- English
- Weight
- 216 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1073-6085
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The tat regulatory protein of HIV-1 was expressed as a fusion protein in E. coli and used as antigen to detect antibodies against HIV-tat (anti-tat) in the serum of HIV-1 infected children and adults. HIV-1-infected children showed a higher frequency (55%) of anti-tat than HIV-1-infected adults (36%
## Abstract Recently, a series of KNI compounds such as KNIโ227 and KNIโ272 has been synthesized and shows potent and selective HIVโ1 protease inhibitory activity __in vitro__. In this study, we developed an HPLC assay system for KNIโ227 and KNIโ272 in rat plasma and examined the pharmacokinetic ch