## Abstract BALB/c mice rendered chimeric at birth by injection of 10^8^ (A/J × BALB/c)F^1^ spleen cells develop a lupus‐like autoimmune disease linked to the activation of donor B cells by host T cells. As __in vitro__ studies previously indicated that interleukin 4 (IL4) was a mediator of the int
✦ LIBER ✦
In vivo administration of interleukin 1 elicits increased Ia antigen expression on B cells through the induction of interleukin 4
✍ Scribed by Loran M. Killar; Cheryl A. Hatfield; Simon R. Carding; Mary Pan; Gregory E. Winterrowd; Kim Bottomly
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 547 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0014-2980
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## Abstract The basis of the adjuvant effect of IL‐1 on the clonal expansion of Ag‐specific CD4 T cells was measured __in vivo__ using the TCR transgenic T cell adoptive transfer method. Injection ofAg plus IL‐1 caused naive CD4 T cells to proliferate to a greater extent than did injection of Ag al