Expression Profiling of Human Breast Cancers and Gene Regulation by Progesterone Receptors
โ Scribed by Britta M. Jacobsen; Jennifer K. Richer; Carol A. Sartorius; Kathryn B. Horwitz
- Book ID
- 111593700
- Publisher
- Springer US
- Year
- 2003
- Tongue
- English
- Weight
- 386 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1083-3021
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Absence of estrogen receptor (ER) and progesterone receptor (PR) is the hallmark of most hormone-independent breast cancers. Previous studies demonstrated that reactivation of PR expression in hormone-independent MDA-MB-231 breast cancer cells enabled progesterone to suppress cell growth both in vit
Although the androgen receptor (AR) has been detected by ligand-binding assays, there is little known about the expression and regulation of the AR gene in human breast-cancer cells. AR mRNA, measured by Northern analysis in 18 cell lines, was found to be expressed predominantly in oestrogen-and pro