✦ LIBER ✦

Regulation of androgen receptor gene expression by steroids and retinoic acid in human breast-cancer cells

✍ Scribed by Rosemary E. Hall; Wayne D. Tilley; Michael J. McPhaul; Robert L. Sutherland

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 993 KB
Volume: 52
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910520518

No coin nor oath required. For personal study only.

✦ Synopsis

Although the androgen receptor (AR) has been detected by ligand-binding assays, there is little known about the expression and regulation of the AR gene in human breast-cancer cells. AR mRNA, measured by Northern analysis in 18 cell lines, was found to be expressed predominantly in oestrogen-and progesterone-receptor-positive (ER+, PR+) lines as a single species of approximately 10.5 kb but was also comparatively abundant in I ER-and PR-negative cell line, MDA-MB-453. Dexamethasone

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