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Expression pattern of galectin-3 in neural tumor cell lines

✍ Scribed by Stephan Kuklinski; Penka Pesheva; Cornelia Heimann; Stephanie Urschel; Sergio Gloor; Sebastian Graeber; Volker Herzog; Torsten Pietsch; Otmar D. Wiestler; Rainer Probstmeier

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
482 KB
Volume
60
Category
Article
ISSN
0360-4012

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✦ Synopsis

Galectin-3 is a member of the galectin family of ␀-galactoside-specific animal lectins. Here we show that galectin-3 is constitutively expressed in 15 out of 16 glioma cell lines tested, but not by normal or reactive astrocytes, oligodendrocytes, glial O-2A progenitor cells and the oligodendrocyte precursor cell line Oli-neu. Galectin-3 is also expressed by one oligodendroglioma cell line, but not by primitive neuroectodermal tumor and 4 neuroblastoma cell lines tested so far. In all galectin-3 expressing cell lines, the lectin is predominantly, if not exclusively, localized intracellularly and carries an active carbohydrate recognition domain (shown for C6 rat glioma cells). Moreover, in contrast to primary astrocytes, glioma cells do not or only weakly adhere to substratum-bound galectin-3, probably reflecting an unusual glycosylation pattern. Our findings indicate that the expression of galectin-3 selectively correlates with glial cell transformation in the central nervous system and could thus serve as a marker for glial tumor cell lines and glial tumors.

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