We investigated the regulation of collagenase-3 expression in normal, differentiating rat osteoblasts. Fetal rat calvarial cell cultures showed an increase in alkaline phosphatase activity reaching maximal levels between 7-14 days postconfluence, then declining with the onset of mineralization. Coll
Regulation of collagenase-3 gene expression in osteoblastic and non-osteoblastic cell lines
โ Scribed by Nagarajan Selvamurugan; Regina J. Brown; Nicola C. Partridge
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 191 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0730-2312
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The mouse Cbfa1 gene potentially encodes several proteins that differ in their N-terminal sequences, including an osteoblast-specific transcription factor, Cbfa1/Osf2, a Cbfa1 isoform (Cbfa1/iso), and the originally described Cbfa1 gene product (Cbfa1/org). Uncertainty exists about the function of t
We have previously described a specific, saturable receptor for rat collagenase-3 in the rat osteosarcoma cell line, UMR 106-01. Binding of rat collagenase-3 to this receptor is coupled to the internalization and eventual degradation of the enzyme and correlates with observed extracellular levels of