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Expression of Urokinase-Type Plasminogen Activator and Its Receptor in Gastric Fibroblasts and Effects of Nonsteroidal Antiinflammatory Drugs and Prostaglandin

✍ Scribed by Jun-Ichi Iwamoto; Kimiko Takahashi; Yuji Mizokami; Toshiya Otsubo; Syuuhei Miura; Toshiaki Narasaka; Hiroki Takeyama; Takayuki Omata; Kouichi Shimokoube; Takeshi Matsuoka

Book ID: 111578768
Publisher: Springer US
Year: 2003
Tongue: English
Weight: 184 KB
Volume: 48
Category: Article
ISSN: 0163-2116
DOI: 10.1023/b:ddas.0000007859.10680.b1

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The urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in tumour invasion. Previous studies have shown by RT-PCR that uPA and uPAR mRNAs are expressed in human hepatocellular carcinoma (HCC). Here, in situ hybridization, immunohistochemistry, and double immuno¯