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Expression of the β-nerve growth factor gene in male sex organs of the mouse, rat, and guinea pig

✍ Scribed by D. MacGrogan; G. Desprès; R. Romand; Dr. E. Dicou

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
584 KB
Volume
28
Category
Article
ISSN
0360-4012

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✦ Synopsis

Steady-state nerve growth factor (NGF) mRNA levels were estimated in male sex organs of the mouse, rat, and guinea pig by RNA blot hybridization analysis. The abundance of NGF mRNAs was in the order vas deferens > epididymis L seminal vesicles >> testis.

NGF mRNA levels in these organs were compared with those estimated for other rat peripheral tissues and were found to correlate with the density of their sympathetic innervation, with the exception of guinea pig prostate. Castration had no significant effect on NGF mRNA levels in the guinea pig prostate, suggesting that NGF synthesis in this tissue is not under direct androgen control. NGF-like and proNGF-like immunoreactivities were localized by immunohistochemical techniques in the secretory cells of the glandular epithelium of the guinea pig prostate and in germ cells in the seminiferous tubules of the mouse testis.

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