Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin's Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells
β Scribed by Karl R.N. Baumforth; Anna Birgersdotter; Gary M. Reynolds; Wenbin Wei; Georgia Kapatai; Joanne R. Flavell; Emma Kalk; Karen Piper; Steve Lee; Lee Machado; Kerry Hadley; Anne Sundblad; Jan Sjoberg; Magnus Bjorkholm; Anna A. Porwit; Lee-Fah Yap; Soohwang Teo; Richard G. Grundy; Lawrence S. Young; Ingemar Ernberg; Ciaran B.J. Woodman; Paul G. Murray
- Book ID
- 117970756
- Publisher
- American Society for Investigative Pathology
- Year
- 2008
- Tongue
- English
- Weight
- 394 KB
- Volume
- 173
- Category
- Article
- ISSN
- 0002-9440
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A new monoclonal antibody bas been used to examine immunohistochemically the expression of the Epstein-Barr virus (EBV)encoded nuclear antigen (EBNA) 1 in virus-associated epithelial lesions. EBNAl was detected in the tumour cell nuclei of 10113 undifferentiated nasopharyngeal carcinomas and of 1011
Fifty-five cases of non-Hodgkin's lymphoma (NHL) of the upper respiratory tract, comprising 27 sinonasal (SN) and 28 Waldeyer's ring (WR) NHL, were investigated for expression of Epstein-Barr virus (EBV)-encoded EBER transcripts and latent membrane protein-1 (LMP-1) by RNA in-situ hybridization (RIS