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Proteasome inhibitors induce the presentation of an Epstein–Barr virus nuclear antigen 1-derived cytotoxic T lymphocyte epitope in Burkitt’s lymphoma cells

✍ Scribed by Federica Destro; Fabio Sforza; Mariaconcetta Sicurella; Diego Marescotti; Eleonora Gallerani; Anna Baldisserotto; Mauro Marastoni; Riccardo Gavioli


Book ID
108782877
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
421 KB
Volume
133
Category
Article
ISSN
0019-2805

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## Abstract EBV‐infected cells and EBV‐associated tumors may evade CTL recognition by defective antigen processing, resulting in poor presentation of CTL epitopes. Since the proteasome is the major source of MHC class I–presented peptides, we analyzed the effect of proteasome inhibitors on the expr