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Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma

✍ Scribed by Shigeki Sekine; Reiko Ogawa; Hidenori Ojima; Yae Kanai

Book ID
108589090
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
599 KB
Volume
102
Category
Article
ISSN
1347-9032

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## Abstract β‐Catenin plays a key role in the Wnt signaling pathway, and mutations of __CTNNB1__, the gene that encodes β‐catenin, have been identified in about one‐fourth of human hepatocellular carcinomas from regions of low aflatoxin B1 exposure. In this study 62 hepatocellular carcinomas (HCCs)