Expression of PEA3 and Lack of Correlation Between PEA3 and HER-2/neuExpression in Breast Cancer
✍ Scribed by Wei-Ya Xia; Huang-Chun Lien; Shao-Chun Wang; Yung Pan; Aysegul Sahin; Yau-Hung Kuo; King-Jeng Chang; Xin Zhou; Hongying Wang; Zhengming Yu; Gabriel Hortobagyi; Dar-Ren Shi; Mien-Chie Hung
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 333 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The PEA3 group of transcription factors belongs to the ets family and is composed of 3 known members, PEA3, ERM and ER81, which are more than 95% identical within the DNAbinding ETS domain and exhibit 50% aa identity overall. Recently, transgenic mice bearing the c-erbB-2/neu oncogene have been show
## Abstract Strong expression of human epidermal growth factor receptor 2 (HER‐2)/neu in breast cancer has been associated with poor prognosis. Reduced expression of p27^Kip1^, a cyclin‐dependent kinase inhibitor, correlates with poor clinical outcome in breast cancer. In this study, we provide a c
## Abstract Polyomavirus enhancer activator 3 (PEA3) is a member of the Ets family of transcription factors. We demonstrated in a previous study that, by downregulating the HER‐2/neu oncogene at the transcriptional level, PEA3 can inhibit the growth and development into tumors of HER‐2/neu‐overexpr
## Abstract The expression level of strometysin‐3 (ST3) mRNA was analyzed by in situ hybridization of formalin‐fixed, paraffin‐embedded primary breast‐tumor samples from 76 patients. Digital image analysis of the dark‐field __in situ__ hybridization signal was used to measure the maximal level of S