𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Correlation between stromelysin-3 mRNA level and outcome of human breast cancer

✍ Scribed by Georg Engel; Kerstin Heselmeyer; Gert Auer; Martin Bäckdahl; Elina Eriksson; Stig Under

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
836 KB
Volume
58
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The expression level of strometysin‐3 (ST3) mRNA was analyzed by in situ hybridization of formalin‐fixed, paraffin‐embedded primary breast‐tumor samples from 76 patients. Digital image analysis of the dark‐field in situ hybridization signal was used to measure the maximal level of ST3 expression in each tumor. All 55 invasive ductal carcinomas and 9 of 10 invasive lobular carcinomas were positive for ST3. Invasive tumors had significantly higher levels of ST3 than in situ tumors. Furthermore, ST3 levels were higher in invasive ductal carcinomas than in invasive lobular carcinomas. The ST3 expression level was significantly correlated to fatal metastatic disease (mean follow‐up 104 months). ST3 levels of < 2,500 units were associated with distant metastasis in 46% of patients, whereas levels of >2,500 units were associated with metastasis in 79% of patients selected for study. ST3 mRNA levels did not correlate with tumor siie, microvessel density, DNA pioidy or estrogen‐receptor levels. Studies of ST3 expression may provide information valuable for the understanding of breast cancer biology and for prognosis.

📜 SIMILAR VOLUMES

Modulation of human stromelysin 3 promot
Modulation of human stromelysin 3 promoter activity and gene expression by human breast cancer cells
✍ Athar Ahmad; John F. Marshall; Paul Basset; Patrick Anglard; Ian R. Hart 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 177 KB 👁 2 views

The matrix-degrading enzyme family of matrix-metalloproteinases (MMPs) has been implicated in the process of tumour metastasis. Cellular protein and RNA localisation techniques have been used to show that, whilst several MMP genes are expressed in both cancer and stromal cells, stromelysin 3 is expr

Correlation of cyclin D1 mRNA levels wit
Correlation of cyclin D1 mRNA levels with clinico-pathological parameters and clinical outcome in human breast carcinomas
✍ Toshiaki Utsumi; Noriko Yoshimura; Morito Maruta; Shinji Takeuchi; Jiro Ando; Yo 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 90 KB 👁 3 views

In order to evaluate the prognostic significance of cyclin D1 mRNA expression in mammary neoplasia, its levels were measured in 97 breast cancers by reverse transcription-polymerase chain reaction (PCR) using fluorescent primer and standard RNA along with estrogen receptor (ER). The median value of

Quantitative correlation between 1H MRS
Quantitative correlation between 1H MRS and dynamic contrast-enhanced MRI of human breast cancer
✍ Hyeon-Man Baek; Hon J. Yu; Jeon-Hor Chen; Orhan Nalcioglu; Min-Ying Su 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 578 KB

Proton magnetic resonance spectroscopy ( 1 H MRS) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) provide functional information, including vascular volume, vascular permeability and choline (Cho) metabolism. In this study, we applied these two imaging modalities to quantitative

Identification of an exon 3 deletion spl
Identification of an exon 3 deletion splice variant androgen receptor mRNA in human breast cancer
✍ Xiang Zhu; Angela A.I. Daffada; Christina M.W. Chan; Mitchell Dowsett 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 241 KB 👁 2 views

Androgens and androgen receptor (AR) are involved in many regulatory processes in the growth of female breast cells. Mutations in the AR gene and/or alterations of the AR protein sequence may be related to the development and progression of breast cancer. Using reverse transcriptionpolymerase chain