Expression of p53 gene product in oral squamous cell carcinoma in ill-fitting denture wearers and smokers
β Scribed by M. Wakami; M. Fukumoto; M. Aida; H. Yamamoto
- Book ID
- 117612231
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 224 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0901-5027
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To examine the expression of p53 protein and gene alterations in oral epithelial lesions including epithelial dysplasias and primary squamous cell carcinomas, immunohistochemical and temperature gradient gel electrophoresis (TGGE) methods were applied to formalin-fixed and paraffin-embedded tissues.
Previous studies of oral cancer have suggested that alterations of the p53 tumour suppressor gene occur early in the precancerous stage of development. However, these observations have been based on cross-sectional assessment of abnormal p53 protein staining by immunohistochemistry and may not neces
## Esophageal cancer (EC) in the Indian population presents in advanced stages with poor prognosis and warrants the identification of a non-invasive marker for early detection and better prognostic assessment. We have previously reported high prevalence of p53 protein accumulation in esophageal squ