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Expression of p53 in oral mucosal hyperplasia, dysplasia and squamous cell carcinoma

โœ Scribed by D. Kerdpon; AM Rich; PC Reade


Book ID
111271621
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
534 KB
Volume
3
Category
Article
ISSN
1354-523X

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To examine the expression of p53 protein and gene alterations in oral epithelial lesions including epithelial dysplasias and primary squamous cell carcinomas, immunohistochemical and temperature gradient gel electrophoresis (TGGE) methods were applied to formalin-fixed and paraffin-embedded tissues.

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Previous studies of oral cancer have suggested that alterations of the p53 tumour suppressor gene occur early in the precancerous stage of development. However, these observations have been based on cross-sectional assessment of abnormal p53 protein staining by immunohistochemistry and may not neces