✦ LIBER ✦

Expression of nerve growth factor receptors by human peripheral blood mononuclear cells

✍ Scribed by B. Morgan; L. W. Thorpe; D. Marchetti; Dr. J. R. Perez-Polo

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 517 KB
Volume: 23
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490230106

No coin nor oath required. For personal study only.

✦ Synopsis

In the rat, nerve growth factor (NGF) has been shown to affect immune reactivity by binding to cell surface receptors on a subpopulation of splenic mononuclear cells. This binding occurs in a specific and saturable fashion to what appear to be low-affinity (type 11) NGF receptors (NGFR). Immunofluorescence studies here showed that NGFR are also present on a proportion of human peripheral blood mononuclear cells (PBMC). Equilibrium binding studies demonstrated that the binding of NGF to its receptors on PBMC occurs with a single equilibrium binding constant (mean) of 2.11 X M. The number of receptors per cell was determined to be approximately 6.94 X lo3 receptorskell. These results would suggest a role for NGF in the regulation of immune function in man, as well as in animals.

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