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Nerve growth factor receptor gene expression in human peripheral blood lymphocytes in aging

✍ Scribed by Smita D. Kittur; L. Song; H. Endo; W. H. Adler

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
515 KB
Volume
32
Category
Article
ISSN
0360-4012

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✦ Synopsis

Nerve growth factor (NGF) has a modulating effect on immune function, which may occur as a consequence of binding to the NGF receptor (NGF-R). To determine if mRNA for the gene coding for p75NGFR (low affinity NGF-R) is present in lymphocytes, Northern blot analysis of mRNA from human peripheral blood lymphocytes (PBL) and purified T lymphocytes was initiated using cDNA probe for human ~7 5 ~~~~.

p75NGFR mRNA was present in PBL and T lymphocytes, and the mRNA in response to phytohemagglutinin stimulation showed maximum levels at 14 hr of stimulation. p75NGFR mRNA content when analyzed in PBL and T cells from volunteers of various ages showed that p75NGFR mRNA expression does not change with the age of the cell donor.

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