Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder
β Scribed by Wright, C; Mellon, K; Johnston, P; Lane, DP; Harris, AL; Horne, CHW; Neal, DE
- Book ID
- 109836584
- Publisher
- Nature Publishing Group
- Year
- 1991
- Tongue
- English
- Weight
- 851 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0007-0920
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ful in predicting the clinical outcome of transitional cell carcinoma of the bladder, they also create uncertainty. Immunohistochemical staining for p53, MIB-1, epi-
Expression of the c-erbB3 protein was determined in transitional cell carcinoma of the bladder by immunohistochemistry. Strong membrane staining was observed in 10 per cent of cases (7/70) and cytoplasmic and membrane overexpression in 20 per cent (14/70). Overexpression of the epidermal growth fact
Seventy-nine transitional cell carcinomas (TCCs) of the urinary bladder (25 grade 1, 22 grade 2, and 32 grade 3 tumours) were examined for p53 overexpression by immunohistochemistry with a monoclonal antibody and for human papillomavirus (HPV) infection by the polymerase chain reaction (PCR). Positi