Transforming growth factor-alpha (TGF␣) is an epidermal growth factor receptor (EGFR) ligand which is distinguished from EGF by its acid-labile structure and potent transforming function. We recently reported that TGF␣ induces less efficient EGFR heterodimerization and downregulation than does EGF (
Evaluation of epidermal growth factor receptor, transforming growth factor alpha, epidermal growth factor and c-erbB2 in the progression of invasive bladder cancer
✍ Scribed by Ravery, V. ;Grignon, D. ;Angulo, J. ;Pontes, E. ;Montie, J. ;Crissman, J. ;Chopin, D.
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 844 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0300-5623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## BACKGROUND. Cleavage of membrane‐anchored heparin‐binding epidermal growth factor‐like growth factor (proHB‐EGF) yields a soluble HB‐EGF isoform (sHB‐EGF), which is an activating epidermal growth factor receptor (EGFR) ligand and a C‐terminal fragment HB‐EGF‐C acting directly in the
We have investigated the actions of transforming growth factor (TGF) type a on epidermal growth factor (EGF) receptor mRNA expression in MDA-468 human mammary carcinoma cells in serum-free media. We found that exposure of MDA-468 cells to TGFa results in elevated levels of EGF receptor mRNA. This in
Bladder cancers frequently exhibit an increased number of epidermal growth factor receptors (EGFR) in comparison to normal urothelium. The EGFR could potentially be a target for toxic conjugates. The aim of our study was to compare the expression of EGFR in metastases with concurrent or primary tumo