𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Expression of epidermal growth factor receptor in urinary bladder cancer metastases

✍ Scribed by Peter Bue; Kenneth Wester; Anna Sjöström; Anders Holmberg; Sten Nilsson; Jörgen Carlsson; Jan-Erik Westlin; Christer Busch; Per-Uno Malmström

Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
518 KB
Volume
76
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Bladder cancers frequently exhibit an increased number of epidermal growth factor receptors (EGFR) in comparison to normal urothelium. The EGFR could potentially be a target for toxic conjugates. The aim of our study was to compare the expression of EGFR in metastases with concurrent or primary tumour in the urinary bladder using immunohistochemical techniques and a monoclonal antibody. Tumour material from 20 patients was investigated. The majority (13/20) of the metastases were homogeneously stained and showed a moderate to strong membranous staining for EGFR. The expression of EGFR in primary bladder tumours and metastases was similar. There was no indication that tumour tissue exposed to chemotherapy or radiation had a decreased number of EGFR. Targeting of the EGFR thus seems potentially applicable to metastatic disease.

📜 SIMILAR VOLUMES

Detection of circulating cancer cells ex
Detection of circulating cancer cells expressing uroplakins and epidermal growth factor receptor in bladder cancer patients
✍ Iman Osman; Melissa Kang; Andy Lee; Fang-Ming Deng; David Polsky; Maryann Mikhai 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 141 KB 👁 1 views

## Abstract Our purpose was to determine the clinical relevance of the detection of circulating tumor cells (CTCs) expressing urothelial and epithelial markers in bladder cancer patients. Sixty‐two patients who presented to Memorial Sloan‐Kettering Cancer Center between July 2000 and September 2001

Heparin-binding epidermal growth factor-
Heparin-binding epidermal growth factor-like growth factor isoforms and epidermal growth factor receptor/ErbB1 expression in bladder cancer and their relation to clinical outcome
✍ Christopher Kramer; Kai Klasmeyer; Hans Bojar; Wolfgang A. Schulz; Rolf Ackerman 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 313 KB 👁 1 views

## Abstract ## BACKGROUND. Cleavage of membrane‐anchored heparin‐binding epidermal growth factor‐like growth factor (proHB‐EGF) yields a soluble HB‐EGF isoform (sHB‐EGF), which is an activating epidermal growth factor receptor (EGFR) ligand and a C‐terminal fragment HB‐EGF‐C acting directly in the

Differential expression of epidermal gro
Differential expression of epidermal growth factor receptor in human head and neck cancers
✍ Li Dao Ke; Karen Adler-Storthz; Gary L. Clayman; Alfred W. K. Yung; Zhuo Chen 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB 👁 2 views

## Background: Over-expression of human epidermal growth factor receptor (egfr) is associated with a variety of human malignancies, including head and neck cancer. it has also been studied for its effect on cancer cell responses to chemotherapy. to accurately measure changes in egfr expression that