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EXPRESSION OF THE TYPE 1 TYROSINE KINASE GROWTH FACTOR RECEPTORS EGF RECEPTOR, c-erbB2 AND c-erbB3 IN BLADDER CANCER

✍ Scribed by RAJKUMAR, THANGARAJAN; STAMP, GORDON W. H.; PANDHA, HARDEV S.; WAXMAN, JONATHAN; GULLICK, WILLIAM J.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
704 KB
Volume
179
Category
Article
ISSN
0022-3417

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✦ Synopsis

Expression of the c-erbB3 protein was determined in transitional cell carcinoma of the bladder by immunohistochemistry. Strong membrane staining was observed in 10 per cent of cases (7/70) and cytoplasmic and membrane overexpression in 20 per cent (14/70). Overexpression of the epidermal growth factor (EGF) receptor (36 per cent, 25/70) and c-erbB2 proteins (9 per cent 6/70) was determined in the same series of cases. c-erbB3 overexpression was positively correlated with EGF receptor expression (P<0-025) but appeared to be inversely associated with c-erbB2 overexpression. KEY WORDS+pidermal growth factor receptor; c-erbB2; c-erbB3; bladder cancer; oncogenes

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