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Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

โœ Scribed by Greenberg, Roger A; Allsopp, Richard C; Chin, Lynda; Morin, Gregg B; DePinho, Ronald A


Book ID
110061424
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
513 KB
Volume
16
Category
Article
ISSN
0950-9232

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The human telomerase reverse transcriptase (TERT) gene is transcriptionally inactivated in most differentiated cells but is reactivated in the majority of cancer cells. To elucidate how TERT is inactivated during differentiation, we applied all-trans retinoic acid (ATRA) to induce the differentiatio