Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development

Regulation of telomerase by alternate sp

Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium

✍ Gary A. Ulaner; Ji-Fan Hu; Thanh H. Vu; Haritha Oruganti; Linda C. Giudice; Andr 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 252 KB 👁 2 views

Telomerase extends telomeric repeats at the ends of linear chromosomes, thereby prolonging the replicative capacity of cells. To investigate possible regulatory mechanisms of telomerase, we measured telomerase enzyme activity, human telomerase RNA (hTR) and human telomerase reverse transcriptase (hT