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Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications

✍ Scribed by Beatriz Godoi Cavalheiro; Consuelo Rodrigues Junqueira; Lenine Garcia Brandão

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
324 KB
Volume
32
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

Clinical and pathologic examinations cannot always provide a prognosis for patients with medullary thyroid carcinoma. Membrane type 1 matrix metalloproteinase (MT1‐MMP) can act directly on carcinogenesis and takes part in 1 of the processes of metalloproteinase 2 activation, an enzyme related to prognostic impairment of patients with such tumor.

Methods.

Thirty‐five patients who were submitted to surgery were followed up for an average of 74 months. Postoperative and final medical conditions were characterized for comparison with MT1‐MMP immunostainings, performed in surgical paraffin blocks. A value of p < .05 was considered statistically significant.

Results.

Proposed index (association of proportion and intensity of immunostaining) and proportion of immunostained cells in primary specimens were correlated with cure or persistence after initial operations (p = .0216 and p = .0098, respectively).

Conclusion.

MT1‐MMP immunostaining in primary tumor specimens is a new and complementary prognostic predictor in patients with medullary thyroid carcinomas. © 2009 Wiley Periodicals, Inc. Head Neck, 2010

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