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Increased expression of membrane type 1-matrix metalloproteinase in head and neck carcinoma

✍ Scribed by Tomokazu Yoshizaki; Hiroshi Sato; Yumiko Maruyama; Shigeyuki Murono; Mitsuru Furukawa; Chang-Soo Park; Motoharu Seiki

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 117 KB
Volume: 79
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19970101)79:1<139::aid-cncr20>3.0.co;2-4

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

Three types of membrane type-matrix metalloproteinases (mt-mmps) have been identified as activators of pro-mmp2 (gelatinase a/72-kilodalton type iv collagenase), which is believed to be crucial for tumor invasion and metastasis. mt1-mmp has been shown to be widely expressed in various tissues and to be overexpressed in lung and gastric carcinomas.

Methods:

Activation of pro-mmp2 was examined in head and neck squamous cell carcinoma (hnscc) by gelatin zymography. the expression of the mt1-mmp mrna transcript was studied by northern hybridization and that of mt1-mmp protein by immunohistochemical staining with a monoclonal antibody against mt1-mmp.

Results:

Activation of pro-mmp2 was observed in ten of ten hnscc tissues. increased expression of the mt1-mmp mrna transcript was also detected in eight of eight of these tissues. mt1-mmp positive cells were detected at the tumor cell lesions in the majority of these carcinoma tissues by immunohistochemical staining (24 of 27). mt1-mmp expression was more intense in moderately and well differentiated tumors than in poorly differentiated ones (p < 0.05).

Conclusions:

These results suggest that mt1-mmp is involved in the activation of pro-mmp2 in hnscc. these findings suggest that mt1-mmp is significant not only as a tumor marker but as a new target for chemotherapy against hnscc.

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