## Background: Matrix metalloproteinase-2 (mmp-2), which degrades the extracellular matrix or the basement membrane, has an essential role in tumor invasion and metastasis. to evaluate the roles of mmp-2, its inhibitor (tissue inhibitor of metalloproteinase-2 [timp-2]), and its activator (membrane-
Prognostic impact of tissue inhibitor of matrix metalloproteinase-1 in esophageal carcinoma
โ Scribed by Masaki Mori; Koshi Mimori; Noriaki Sadanaga; Hiroshi Inoue; Yoichi Tanaka; Ken-ichi Mafune; Hiroaki Ueo; Graham F. Barnard
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 86 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0020-7136
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## Background: The balance between matrix metalloproteinases (mmp) and the tissue inhibitors of metalloproteinases (timp) has been seen as important during tumor invasion and progression. the determination of these components needs a special strategy of tissue preparation. this analytical problem h
Degradation of the extracellular matrix (ECM) is an essential step in tumour invasion and metastasis. The matrix metalloproteinases (MMPs) each have different substrate specificities within the ECM and are important in its degradation. MMP activity is dependent on the levels of activated MMP and tis
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