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Expression of malignancy in hybrids between normal and malignant cells

✍ Scribed by Carlo M. Croce; Joan Barrick; Alban Linnenbach; Hilary Koprowski

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
535 KB
Volume
99
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Somatic cell hybrids between either normal human fibroblasts, phenotypically normal mouse fibroblasts or mouse peritoneal macrophages and HT1080 human diploid fibrosarcoma cells were studied for their ability to form tumors in nude mice. The results of this study indicate that tumorigenic behavior is expressed as a dominant trait in both human‐human and mouse‐human hybrid cells.

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