The human genes MAGE-I and -3 encode melanoma peptide antigens that are recognized by autologous cytotoxic T lymphocytes. Tumors expressing MAGE genes are potential targets for cancer immunotherapy, because MAGE genes are expressed only in tumor tissue and not in any normal tissue except testis and
Expression of MAGE-1 Gene by Esophageal Carcinomas
β Scribed by Toh, Yuji ;Yamana, Hideaki ;Shichijo, Shigeki ;Fujita, Hiromasa ;Tou, Uhi ;Sakaguchi, Minako ;Kakegawa, Teruo ;Itoh, Kyogo
- Book ID
- 108581003
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1995
- Tongue
- English
- Weight
- 457 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0910-5050
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π SIMILAR VOLUMES
## Human gene MAGE-I codes for an antigen that is recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). This antigen is potentially useful as a target for cancer immunotherapy because gene MAGE-I is not expressed in any normal tissues except the testis. We tested 46 surgical sa
ized in a human melanoma cell line (MZ2-MEL). 4 Expression The MAGE-1 gene, originally isolated from a human of the MAGE-1 gene on HLA-A1 positive tumor cells directs melanoma cell line, directs the expression of a potential the expression of a nonapeptide that allows specific recognitumor-rejection