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Expression of mage genes by non-small-cell lung carcinomas

✍ Scribed by P. Weynants; B. Lethé; F. Brasseur; M. Marchand; T. Boon

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
574 KB
Volume
56
Category
Article
ISSN
0020-7136

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✦ Synopsis

Human gene MAGE-I codes for an antigen that is recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL).

This antigen is potentially useful as a target for cancer immunotherapy because gene MAGE-I is not expressed in any normal tissues except the testis. We tested 46 surgical samples of non-small-cell lung carcinomas and observed MAGE-I expression in 16 of them (35%). Genes MAGE-2 and 3, which are closely related to MAGE-I, were expressed by a similar proportion of these tumors. Some small-cell lung tumors also express MAGE genes. The proportion of tumors expressing MAGE-I suggests that lung tumor patients may constitute the largest group of patients potentially eligible for pilot studies involving MAGE-I immunization.

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