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Expression of mage genes in transitional-cell carcinomas of the urinary bladder

✍ Scribed by Jean-Jacques Patard; Francis Brasseur; Sixtina Gil-Diez; François Radvanyi; Marie Marchand; Philippe François; Antoine Abi-Aad; Paul Van Cangh; Clément Claude Abbou; Dominique Chopin; Thierry Boon

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
535 KB
Volume
64
Category
Article
ISSN
0020-7136

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✦ Synopsis

Human genes MAG€-I and MAG€-3 code for distinct antigens, which are recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). These antigens may constitute useful targets for anti-cancer immunotherapy, since no expression of MAGE genes has been observed in normal tissues other than testis. Out of 57 samples of primary transitional-cell carcinomas of the bladder, I 2 (2 I YO) expressed MAGE-I and 20 (35%) expressed MAGE-3. All but one of the tumors expressing MAGE-I also expressed MACE-3. Genes MACE-2 and MACE-4. which are closely related to MAGE-I and MAGE-3, were expressed by 30% and 33% of the tumors respectively. MAGE expression was more frequent in advanced tumor stages: 6 I Yo

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