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Human esophageal carcinomas frequently express the tumor-rejection antigens of MAGE genes

✍ Scribed by Hiroshi Inoue; Masaki Mori; Jian Li; Koshi Mimori; Masayuki Honda; Hideaki Nakashima; Ken-Ichi Mafune; Youichi Tanaka; Tsuyoshi Akiyoshi

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
462 KB
Volume
63
Category
Article
ISSN
0020-7136

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✦ Synopsis

The human genes MAGE-I and -3 encode melanoma peptide antigens that are recognized by autologous cytotoxic T lymphocytes. Tumors expressing MAGE genes are potential targets for cancer immunotherapy, because MAGE genes are expressed only in tumor tissue and not in any normal tissue except testis and placenta. However, little is known about MAGE gene expression in human esophageal carcinoma. The purpose of this study was therefore to analyze MAGE gene status in human esophageal carcinoma. We studied the expression status of these genes in 42 surgical samples and in I2 cell lines of human esophageal carcinoma using the reverse transcription polymerase chain reaction (RT-PCR). Various clinicopathological factors were also analyzed. N o MAGE gene expression was seen in any

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