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Frequent alterations in the expression of tumor suppressor genes p16INK4Aand pRb in esophageal squamous cell carcinoma in the Indian population

✍ Scribed by Ranju Ralhan; Robin Mathew; Sonia Arora; Rimple Bahl; Nootan Kumar Shukla; Meera Mathur


Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
234 KB
Volume
126
Category
Article
ISSN
1432-1335

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Status and expression of the p16INK4 gen
✍ Viola CalabrΓ²; Maria Strazzullo; Girolama La Mantia; Monica Fedele; Christian Pa πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 French βš– 648 KB

The p 16INK4 tumor-suppressor gene (also known as CDKNZ, CDK41 and MTSI) encodes a negative regulator of the cell cycle. This gene, located in 9pZ I, is mutated or homozygously deleted in a high percentage of tumor cell lines and specific types of primary tumors. We have examined the status of the p