Expression of lung resistance-related protein, LRP, and multidrug resistance-related protein, MRP1, in normal human lung cells in long-term cultures
β Scribed by Thomas Lehmann; Abdel-Rahman Wageeh Torky; Ekkehard Stehfest; Stefan Hofmann; Heidi Foth
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 388 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0340-5761
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Human non-small-cell lung cancer (NSCLC) is considered to be a chemotherapy-refractory malignancy. The underlying mechanisms remain rather obscure. The multidrug resistanceassociated protein (MRP), mediating a multidrug resistance (MDR) phenotype, has been reported to be overexpressed in several dru
MRP has been identified as another multidrug-resistance (MDR) gene and may be involved in an alternative MDR mechanism in some solid tumors. We investigated the expres- sion of M R P mRNA in multidrug-resistant KB sublines (KB-8-5, KB-CZ, C -W and C A I to), human non-small-cell lung carcinomas (NSC