Arachidonic acid pathway activates multidrug resistance related protein in cultured human lung cells
โ Scribed by Abdelrahman Torky; Anja Raemisch; Felix Glahn; Heidi Foth
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 511 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0340-5761
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๐ SIMILAR VOLUMES
Multidrug resistance (MDR) is a major impediment to successful chemotherapy for lung cancer. Overexpression of multidrug resistance-associated protein 1 (MRP1) appears to be involved in MDR development in lung cancer cells. A number of chemotherapeutic agents including doxorubicin (DOX) were reporte
MRP has been identified as another multidrug-resistance (MDR) gene and may be involved in an alternative MDR mechanism in some solid tumors. We investigated the expres- sion of M R P mRNA in multidrug-resistant KB sublines (KB-8-5, KB-CZ, C -W and C A I to), human non-small-cell lung carcinomas (NSC